Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
oleh: Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may regulate such early development.