Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
oleh: Marion Grard, Marion Grard, Camille Chatelain, Camille Chatelain, Tiphaine Delaunay, Tiphaine Delaunay, Elvire Pons-Tostivint, Elvire Pons-Tostivint, Elvire Pons-Tostivint, Jaafar Bennouna, Jaafar Bennouna, Jaafar Bennouna, Jean-François Fonteneau, Jean-François Fonteneau
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2021-06-01 |
Deskripsi
Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.