Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
oleh: Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J. Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu, Yi-Ping Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.