Repression of GSK3 restores NK cell cytotoxicity in AML patients
oleh: Reshmi Parameswaran, Parameswaran Ramakrishnan, Stephen A. Moreton, Zhiqiang Xia, Yongchun Hou, Dean A. Lee, Kalpana Gupta, Marcos deLima, Rose C. Beck, David N. Wald
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.