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During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-related sarcopenia. Here we studied the role of the mitophagy adaptor BNIP3 in mitochondrial homeostasis and muscle during aging. Our findings reveal that BNIP3 orchestrates mitochondrial and lysosomal function to mitigate muscle inflammation and atrophy during aging.