Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
oleh: Chaitanya Kurhade, Sarah Schreier, Yi-Ping Lee, Loreen Zegenhagen, Marika Hjertqvist, Gerhard Dobler, Andrea Kröger, Anna K. Överby
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2018-09-01 |
Deskripsi
We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.