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The human population’s health, economy, and way of life have been seriously threatened by the Coronavirus Disease (COVID19) pandemic. Patients with cancer are one of the special patient groups who faced additional difficulties during COVID-19, with additional problems in their basket. To minimise the sufferings, regular physical activity of any intensity lowers the chance of cancer progression while enhancing survival rates and Quality of Life (QoL). The lengthy indoor stay during the COVID-19 lockdown prompted inactivity among cancer patients, reducing their overall QoL. The purpose of this article is to ascertain how COVID-19- related physical inactivity affected cancer patients and their QoL.