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Eight indophenines were synthesized for the interest of studying biological activity especially for cytotoxicity. The cytotoxicity of some indophenines and some isatin derivatives was studied by the brine shrimp lethality bioassay. It was observed that all the indophenines from thiophene, thiazol and isatin derivatives showed potential cytotoxicity against brine shrimp nauplii and the Structure Activity Relationships (SAR) of these compounds have been reported.