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We report a case of 7-month-old infant girl with severe uvulitis with airway obstruction. Her uvula was erythematous and markedly swollen. Stridor and retraction were noted. The symptoms were resolved after treatment with ampicillin, and a throat swab isolated Group A streptococcus. It is extremely rare in children for uvulitis to cause respiratory distress from airway obstruction. However, in infants with narrow airways, physicians should consider the risk of progression to respiratory distress.