Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants
oleh: Mariangela Cavarelli, Stéphane Hua, Naima Hantour, Sabine Tricot, Nicolas Tchitchek, Céline Gommet, Hakim Hocini, Catherine Chapon, Nathalie Dereuddre-Bosquet, Roger Le Grand
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Mariangela Cavarelli et al. utilize cynomolgus macaque colorectal tissue explants to explore the effect of leukocytospermic seminal plasma (LSP) on SIVmac251 infection. Their results suggest that mucosal SIV infection is influenced by the inflammatory state of the semen donor, providing further insight into mucosal SIV pathogenesis.