An allosteric ligand-binding site in the extracellular cap of K2P channels
oleh: Qichao Luo, Liping Chen, Xi Cheng, Yuqin Ma, Xiaona Li, Bing Zhang, Li Li, Shilei Zhang, Fei Guo, Yang Li, Huaiyu Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-08-01 |
Deskripsi
TREKs are members of the two-pore domain potassium (K2P) channels, being important clinical targets. Here the authors identify inhibitors of K2P that bind to an allosteric site located in their extracellular cap, suggesting that it might be a promising drug target for these channels.