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In this work dynamics ofinflammatoryandanti-inflammatory cytokines in blood serum of 65 patients with atrophic arthritis depending on activity, duration of inflammatory process, presence or absence of the rheumatoid factor is represented. It is determined: that the level ofФНО-а in blood serum among patients with atrophic arthritis does not depend upon the growth of an inflammatory process’s activity and presence or absence of the rheumatoid factor, but it depends upon the clinical course’s duration. The maintenance of ИФ-у and ИЛ-4 in patients' blood serum with atrophic arthritis depends upon a degree of an inflammatory process’s activity and does not depend upon the clinical course’s duration and presence or absence of the rheumatoid factor.