Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
The developing brain structural and functional connectome fingerprint
oleh: Judit Ciarrusta, Daan Christiaens, Sean P. Fitzgibbon, Ralica Dimitrova, Jana Hutter, Emer Hughes, Eugene Duff, Anthony N. Price, Lucilio Cordero-Grande, J.-Donald Tournier, Daniel Rueckert, Joseph V. Hajnal, Tomoki Arichi, Grainne McAlonan, A. David Edwards, Dafnis Batalle
Format: | Article |
---|---|
Diterbitkan: | Elsevier 2022-06-01 |
Deskripsi
In the mature brain, structural and functional ‘fingerprints’ of brain connectivity can be used to identify the uniqueness of an individual. However, whether the characteristics that make a given brain distinguishable from others already exist at birth remains unknown. Here, we used neuroimaging data from the developing Human Connectome Project (dHCP) of preterm born neonates who were scanned twice during the perinatal period to assess the developing brain fingerprint. We found that 62% of the participants could be identified based on the congruence of the later structural connectome to the initial connectivity matrix derived from the earlier timepoint. In contrast, similarity between functional connectomes of the same subject at different time points was low. Only 10% of the participants showed greater self-similarity in comparison to self-to-other-similarity for the functional connectome. These results suggest that structural connectivity is more stable in early life and can represent a potential connectome fingerprint of the individual: a relatively stable structural connectome appears to support a changing functional connectome at a time when neonates must rapidly acquire new skills to adapt to their new environment.