Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
oleh: Laura Burbaum, Jonathan Schneider, Sarah Scholze, Ralph T. Böttcher, Wolfgang Baumeister, Petra Schwille, Jürgen M. Plitzko, Marion Jasnin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced order of the thin filaments, their sliding and functional states enabling contraction.