Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation
oleh: Zi-Yi Huang, Min-Ru Jiao, Xiu Gu, Zi-Ran Zhai, Jian-Qi Li, Qing-Wei Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Georg Thieme Verlag KG 2021-09-01 |
Deskripsi
Abstract This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with diastereomeric excess of 94%), which could be used as important raw materials for the preparation of related cannabinoid drugs.