Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment
oleh: Xia Yang, Qiong Liu, Ming-feng Lai, Xiao-hong Ma, Xiao-hong Ma, Xiao-ting Hao, Jia-jun Xu, Wan-jun Guo
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2023-12-01 |
Deskripsi
ObjectiveMetabotropic glutamate receptor 5 (mGluR5) encephalitis is such a rare type of autoimmune encephalitis that its diagnosis remains a challenge.Case reportA 19-year-old female patient initially presented with anxiety and orthostatic leg tremors without cortical dysfunction. We found that this patient was positive for mGluR5 antibodies in both serum (1:1,000) and cerebrospinal fluid (1:32). After comprehensive intervention, the patient showed complete recovery at the 18-month follow-up.DiscussionThis report expands our knowledge of the possible presentations of mGluR5 encephalitis for early diagnosis, which makes it possible to prevent serious consequences and improve the prognosis.