ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
oleh: Himansha Singh, Saroj Velamakanni, Michael J. Deery, Julie Howard, Shen L. Wei, Hendrik W. van Veen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP hydrolysis. Here, the authors show that the bacterial transporter MsbA requires additional energy from the transmembrane electrochemical proton gradient to facilitate drug transport.