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Acinetobacter baumannii is a bacterium that is commonly causes of nosocomial infections, the most common site of infection and colonization is the lower respiratory tract. Although it is present more often in immuno-compromised patients, the defense mechanism against infection with Acinetobacter baumanii remains incomplete elucidated. Among the virulence factors involved in infection with Acinetobacter baumanii are production and release of exopolysaccharide, and ability to biofilm formation in tissues. Understanding of virulence mechanisms is important for early initiation of treatment.