A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
oleh: Joshua M. Hardy, Natalee D. Newton, Naphak Modhiran, Connor A. P. Scott, Hariprasad Venugopal, Laura J. Vet, Paul R. Young, Roy A. Hall, Jody Hobson-Peters, Fasséli Coulibaly, Daniel Watterson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Understanding virus assembly could identify potential drug targets. Here the authors use a safe and efficient method to solve pathogenic flavivirus structures, revealing two lipid-like ligands within highly conserved pockets of the stem region of envelope protein that are important for virus maturation.