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The present study investigated the wound healing activity of <i>Moringa oleifera</i> leaf extract on an infected excision wound model in rats. Infection was induced using methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) or <i>Pseudomonas aeruginosa.</i> An investigation was also done to study the effect of <i>Moringa</i> extract on the vascular endothelial growth factor (VEGF) and transforming growth factor-beta 1 (TGF-β1) gene expression in vitro using human keratinocytes (HaCaT). The methanol extract of <i>M. oleifera</i> leaves was analyzed for the presence of phytochemicals by LCMS. The antimicrobial activity of the extract was also determined. Wound contraction, days for epithelization, antioxidant enzyme activities, epidermal height, angiogenesis, and collagen deposition were studied. <i>M. oleifera</i> showed an antimicrobial effect and significantly improved wound contraction, reduced epithelization period, increased antioxidant enzymes activity, and reduced capillary density. Effect of the extract was less in wounds infected with <i>P. aeruginosa</i> when compared to MRSA. The VEGF and TGF-β1 gene expression was increased by <i>M. oleifera</i>.