Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
oleh: Sachin S. Katti, Inna V. Krieger, Jihyae Ann, Jeewoo Lee, James C. Sacchettini, Tatyana I. Igumenova
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Protein kinase Cs (PKCs) define a central DAG-sensing node in intracellular phosphoinositide signaling pathways that regulate cell growth, differentiation, apoptosis, and motility. The structures of PKC C1 domain complexes with DAG and 4 agonists reveal the molecular basis of ligand recognition and capture.