Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
oleh: Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.