Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
oleh: Yoonsu Cho, Philip C. Haycock, Eleanor Sanderson, Tom R. Gaunt, Jie Zheng, Andrew P. Morris, George Davey Smith, Gibran Hemani
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-02-01 |
Deskripsi
In Mendelian randomization (MR) studies, one typically selects SNPs as instrumental variables that do not directly affect the outcome to avoid violation of MR assumptions. Here, Cho et al. present a framework, MR-TRYX, that leverages knowledge of such outliers of horizontal pleiotropy to identify putative causal relationships between exposure and outcome.