Layer-specific cholinergic control of human and mouse cortical synaptic plasticity
oleh: Matthijs B. Verhoog, Joshua Obermayer, Christian A. Kortleven, René Wilbers, Jordi Wester, Johannes C. Baayen, Christiaan P. J. De Kock, Rhiannon M. Meredith, Huibert D. Mansvelder
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and L2/3 in human and mouse cortex and find they mediate opposite effects on synaptic plasticity.