Find in Library

<i>Hericium erinaceus</i>, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of <i>Hericium erinaceus</i> led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (<b>1</b>); and eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl linoleate (<b>2</b>); ethyl linoleate (<b>3</b>); linoleic acid (<b>4</b>); hericene A (<b>5</b>); hericene D (<b>6</b>); hericene E (<b>7</b>); ergosta-4,6,8(14),22-tetraen-3-one (<b>8</b>); hericenone F (<b>9</b>); ergosterol (<b>10</b>); ergosterol peroxide (<b>11</b>); 3β,5α,6α,22<i>E</i>-ergosta-7,22-diene-3,5,6-triol 6-oleate (<b>12</b>). The chemical structures of the compounds were determined by 1D and 2D NMR (nuclear magnetic resonance) spectroscopy, mass spectra, etc. Anti-inflammatory effects of the isolated aromatic compounds (<b>5</b>–<b>7</b>, <b>9</b>) were evaluated in terms of inhibition of pro-inflammatory mediator (TNF-α, IL-6 and NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. The results showed that compounds <b>5</b> and <b>9</b> exhibited moderate activity against TNF-α (IC₅₀: 78.50 μM and 62.46 μM), IL-6 (IC₅₀: 56.33 μM and 48.50 μM) and NO (IC₅₀: 87.31 μM and 76.16 μM) secretion. These results supply new information about the secondary metabolites of <i>Hericium erinaceus</i> and their anti-inflammatory effects.