Assortative mating biases marker-based heritability estimators
oleh: Richard Border, Sean O’Rourke, Teresa de Candia, Michael E. Goddard, Peter M. Visscher, Loic Yengo, Matt Jones, Matthew C. Keller
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
Methods for estimating heritability, the fraction of variance attributable to genetic factors, assume random mating. Here, the authors show that under assortative mating, when mate choice reflects phenotypic similarity, these methods produce overestimates.