ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
oleh: Rajesh Ghai, Ximing Du, Huan Wang, Jiangqing Dong, Charles Ferguson, Andrew J. Brown, Robert G. Parton, Jia-Wei Wu, Hongyuan Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.