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Novel monomethoxy poly(ethylene glycol) (<i>m</i>PEG) modified hydroxylated tung oil (HTO), denoted as <i>m</i>PEG-HTO-<i>m</i>PEG, was designed and synthesized for drug delivery. <i>m</i>PEG-HTO-<i>m</i>PEG consists of a hydroxylated tung oil center joined by two <i>m</i>PEG blocks via a urethane linkage. The properties of <i>m</i>PEG-HTO-<i>m</i>PEG were affected by the length of the mPEG chain. Three <i>m</i>PEG with different molecular weights were used to prepare <i>m</i>PEG-HTO-<i>m</i>PEG. The obtained three <i>m</i>PEG-HTO-<i>m</i>PEG polymers were characterized by nuclear magnetic resonance (NMR), Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC), respectively. Furthermore, the particle sizes of <i>m</i>PEG-HTO-<i>m</i>PEG micelles were evaluated by dynamic light scattering (DLS) and transmission electron microscope (TEM). A critical aggregation concentration (CAC) ranged from 7.28 to 11.73 mg/L depending on the chain length of mPEG. The drug loading and release behaviors of <i>m</i>PEG-HTO-<i>m</i>PEG were investigated using prednisone acetate as a model drug, and results indicated that hydrophobic prednisone acetate could be effectively loaded into <i>m</i>PEG-HTO-<i>m</i>PEG micelles and exhibited a long-term sustained release. Moreover, compared with HTO, <i>m</i>PEG-HTO-<i>m</i>PEG had no obvious cytotoxicity to HeLa and L929 cells. Therefore, monomethoxy poly(ethylene glycol) modified hydroxylated tung oil <i>m</i>PEG-HTO-<i>m</i>PEG may be a promising drug carrier.