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Constraining the duration of magmatism is of vital importance to the understanding of the magmatic-hydrothermal mineral system. The Bozhushan batholith, located in the middle section of the southeastern Yunnan ore district, mainly consists of biotite monzogranite and monzogranite. Many Sn−W−polymetallic deposits are developed around the Bozhushan batholith, but their temporal and genetic relationships remain controversial. LA-ICP-MS U−Pb zircon and monazite dating were respectively conducted on the same two samples, yielding weighted mean ²⁰⁶Pb/²³⁸U zircon ages of 85.1 ± 0.7 and 85.6 ± 0.9 Ma, and weighted mean ²⁰⁶Pb/²³⁸U monazite ages of 87.1 ± 0.9 and 88.1 ± 1.1 Ma. The crystallization ages of S-type granites obtained from the zircon U−Th−Pb system and monazite U−Th−Pb system are consistent within the analytical errors. After combining the new ages obtained in this study with recently published U−Pb zircon and cassiterite ages from the giant Baniuchang Ag−Sn−Pb−Zn deposit in the north, and U−Pb zircon and Re-Os molybdenite ages from the large Guanfang W deposit in the south, a temporal framework of magmatism-mineralization in the Bozhushan region has been established. The duration of magmatic activity at Bozhushan is about 7 Ma, with W mineralization occurring at ca. 92 Ma and Sn mineralization at 88−87 Ma.