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Background: Outbreaks of a new virus called COVID-19 have been reported in China since late December 2019. This study was performed to evaluate the demographic, clinical, paraclinical findings and outcome of patients with the COVID-19 delta strain. Materials and Methods: In this case-series study, 239 patients with delta strain of COVID-19 with positive PCR were selected. The patients' files contained demographic information, clinical symptoms, paraclinical findings and outcome. The collected data were analyzed through SPSS software. Results: Among the studied patients, women were the most frequent with 53.6% and more than half of the patients were over 50 years old. The majority of patients had blood group O (45.2%), and nearly 60% of patients had at least one underlying disease, of which high blood pressure, diabetes and cardiovascular disease are the most common. Nearly 90% of patients did not receive the vaccine. The most common clinical symptoms included fever (60.3%), cough (59.8%) and dyspnea (50.2%). Nearly 90% of patients experienced mild to severe lung involvement, and nearly 75% of patients were in the moderate to severe range of the severity of the COVID-19 disease. Finally, 13 patients (5.4%) died. Conclusion: Considering that most of the patients did not receive the vaccine and also the majority of them were in the moderate to severe phase of the disease, the necessity of receiving the vaccine to prevent the disease of COVID-19 is clear.