Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus
oleh: Vincent Rincheval, Mickael Lelek, Elyanne Gault, Camille Bouillier, Delphine Sitterlin, Sabine Blouquit-Laye, Marie Galloux, Christophe Zimmer, Jean-François Eleouet, Marie-Anne Rameix-Welti
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 protein but exclude viral genomic RNA and RNA polymerase complexes.