Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
oleh: Biao Ma, Hongcheng Cheng, Ruize Gao, Chenglong Mu, Ling Chen, Shian Wu, Quan Chen, Yushan Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-03-01 |
Deskripsi
Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting Lats2 degradation and YAP activation.