Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

oleh: Cheng-Tao Jiang, Kai-Ge Chen, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang

Format: Article
Diterbitkan: Nature Portfolio 2021-03-01

Deskripsi

Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.