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The findings by Yang-TI et al. suggested that macrolide-resistance and/or delayed appropriate antimicrobial treatment may contribute to the development of Mycoplasma pneumoniae-related extra-pulmonary diseases in children. Indeed, these conditions can have variable clinical expression and severity, and may arise in immunologically predisposed children after recurrent/persistent exposure to Mycoplasma pneumoniae. Keywords: Extra-pulmonary diseases, Immune-mediated diseases, Mycoplasma pneumoniae