Whole-Genome Sequencing Analysis of Sapovirus Detected in South Korea.

oleh: Hye Lim Choi, Chang-Il Suh, Seung-Won Park, Ji-Young Jin, Han-Gil Cho, Soon-Young Paik

Format: Article
Diterbitkan: Public Library of Science (PLoS) 2015-01-01

Deskripsi

Sapovirus (SaV), a virus residing in the intestines, is one of the important causes of gastroenteritis in human beings. Human SaV genomes are classified into various genogroups and genotypes. Whole-genome analysis and phylogenetic analysis of ROK62, the SaV isolated in South Korea, were carried out. The ROK62 genome of 7429 nucleotides contains 3 open-reading frames (ORF). The genotype of ROK62 is SaV GI-1, and 94% of its nucleotide sequence is identical with other SaVs, namely Manchester and Mc114. Recently, SaV infection has been on the rise throughout the world, particularly in countries neighboring South Korea; however, very few academic studies have been done nationally. As the first whole-genome sequence analysis of SaV in South Korea, this research will help provide reference for the detection of recombination, tracking of epidemic spread, and development of diagnosis methods for SaV.