Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
oleh: Carine Z. J. Lim, Yan Zhang, Yu Chen, Haitao Zhao, Mary C. Stephenson, Nicholas R. Y. Ho, Yuan Chen, Jaehoon Chung, Anthonin Reilhac, Tze Ping Loh, Christopher L. H. Chen, Huilin Shao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.