Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
oleh: Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell, Kris C. Wood
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
Mitochondrial dynamics regulate critical processes. Here the authors show that genes regulating mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated with changes in drug sensitivity including increased sensitivity to the apoptosis-targeting Smac mimetics.