Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
oleh: Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R. Weiss, Arjun Raj, Daniel Beiting, Carolina B. López
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.