Find in Library

This study investigated the efficacy of a composite probiotics composed of <i>lactobacillus plantarum</i>, <i>lactobacillus reuteri</i>, and <i>bifidobacterium longum</i> in alleviating oxidative stress in weaned piglets and pregnant sows. Evaluations of growth, oxidative stress, inflammation, intestinal barrier, and fecal microbiota were conducted. Results showed that the composite probiotic significantly promoted average daily gain in piglets (<i>p</i> < 0.05). It effectively attenuated inflammatory responses (<i>p</i> < 0.05) and oxidative stress (<i>p</i> < 0.05) while enhancing intestinal barrier function in piglets (<i>p</i> < 0.01). Fecal microbiota analysis revealed an increase in the abundance of beneficial bacteria such as <i>faecalibacterium</i>, <i>parabacteroides</i>, <i>clostridium</i>, <i>blautia</i>, and <i>phascolarctobacterium</i> in piglet feces and <i>lactobacillus</i>, <i>parabacteroides</i>, <i>fibrobacter</i>, and <i>phascolarctobacterium</i> in sow feces, with a decrease in harmful bacteria such as <i>bacteroides</i> and <i>desulfovibrio</i> in sow feces upon probiotic supplementation. Correlation analysis indicated significant negative associations of <i>blautia</i> with inflammation and oxidative stress in piglet feces, while <i>treponema</i> and <i>coprococcus</i> showed significant positive associations. In sow feces, <i>lactobacillus</i>, <i>prevotella</i>, <i>treponema</i>, and <i>CF231</i> exhibited significant negative associations, while <i>turicibacter</i> showed a significant positive association. Therefore, the composite probiotic alleviated oxidative stress in weaned piglets and pregnant sows by modulating fecal microbiota composition.