Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes
oleh: Oleksii A. Skorokhod, Elena V. Kulikova, Ninel M. Galkina, Pavel V. Medvedev, Elena E. Zybunova, Victor M. Vitvitsky, Aleksandr V. Pivnik, Fazoil I. Ataullakhanov
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2007-04-01 |
Deskripsi
Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.