3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
oleh: Lu Yang, Fengling Chen, Haichuan Zhu, Yang Chen, Bingjie Dong, Minglei Shi, Weitao Wang, Qian Jiang, Leping Zhang, Xiaojun Huang, Michael Q. Zhang, Hong Wu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.