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Hodgkin's lymphoma is the third most common cancer in young people between 15 and 34 years of age, with a lower incidence in other age groups and slightly higher in males. The etiology of Hodgkin's lymphoma is still unknown - although various factors influencing the oncogenesis of the disease have been noted, the mechanism of their influence is poorly understood. This article will present the case of a 41-year-old patient with classic Hodgkin's lymphoma - nodular sclerosis histological subtype - chemorefractory.