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Abstract The paper proposes design and investigates controllers for infusion pump systems to actuate air control flow with improved performance. The actuator is realized with a permanent magnet brushless DC motor controlled by a self-tune PID controller replaced self-tune fuzzy-PID controller. Using the nonlinear model of the infusion pump system includes the motor driver, fuzzy-PID controller, and gear head as the load connected to the analysis of experimental results. The proposed control topology will improve transient responses such as rise time and steady-state error of the infusion pump system. The actuation system needs an efficient actuator with a controller for tracking desired response with self-tuning depending on linear and nonlinear conditions. The complete electromechanical actuator for fin control is modeled in MATLAB/SIMULINK environment. The simulation results show a better transient response and fewer torque ripples in the proposed system and a comparison study is performed for fuzzy-PID and conventional PID controllers.