Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome
oleh: Sa A. Wang, Robert P. Hasserjian, Wayne Tam, Albert G. Tsai, Julia T. Geyer, Tracy I. George, Kathryn Foucar, Heesun J. Rogers, Eric D. Hsi, Bryan A. Rea, Adam Bagg, Carlos E. Bueso-Ramos, Daniel A. Arber, Srdan Verstovsek, Attilio Orazi
| Format: | Article |
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| Diterbitkan: | Ferrata Storti Foundation 2017-08-01 |
Deskripsi
Chronic eosinophilic leukemia, not otherwise specified can be difficult to distinguish from idiopathic hypereosinophilic syndrome according to the current World Health Organization guideline. To examine whether the morphological features of bone marrow might aid in the differential diagnosis of these two entities, we studied a total of 139 patients with a diagnosis of chronic eosinophilic leukemia, not otherwise specified (n=17) or idiopathic hypereosinophilic syndrome (n=122). As a group, abnormal bone marrow morphological features, resembling myelodysplastic syndromes, myeloproliferative neoplasm or myelodysplastic/myeloproliferative neoplasm, were identified in 40/139 (27%) patients: 16 (94%) of those with chronic eosinophilic leukemia and 24 (20%) of those with hypereosinophilic syndrome. Abnormal bone marrow correlated with older age (P