Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
oleh: Lin Wang, Li Yan, Jieling Jiang, Yuyi Zhang, Qiyu He, Hui Zhuang, Ling Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2020-01-01 |
Deskripsi
ABSTRACTHepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.