PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
oleh: Benjamin P. Hurrell, Doumet Georges Helou, Emily Howard, Jacob D. Painter, Pedram Shafiei-Jahani, Arlene H. Sharpe, Omid Akbari
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Regulatory T (Treg) cells have been implicated in the induction of airway tolerance and amelioration of respiratory duct inflammation. Here the authors show, using PD-L2 deficient mice, that the immune suppression signal from PD-L2 is important for modulating Treg cell metabolism and function for proper induction of respiratory tolerance in mice.