Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
oleh: Mengjie Hu, Gulimiran Alitongbieke, Ying Su, Hu Zhou, Xiao-kun Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-05-01 |
Deskripsi
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.