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Globally, prematurity is the leading cause of neonatal mortality (babies in the first four weeks of life) and now the second leading cause of mortality after pneumonia in children under age five. The neonatal gut microbial colonization is crucial in the human life cycle. Placental microbiota transmits from the gut microbiota plays a significant role in association with kinship. Simultaneously, this transition is being made from mother to infant. This comparative study explored the diversity of microbiota associated with term and preterm neonates by evaluating the placental samples. The study found that 16/68 (23.5%) full-term placental samples were positive for <i>S. aureus;</i> on the other hand, 4/16 (25%) preterm placental samples confirmed culture growth for <i>S. aureus.</i> Antimicrobial susceptibility patterns showed that <i>Staphylococcus</i><i>aureus</i> (<i>S. aureus</i>) isolates from both types of samples were resistant to Ofloxacin, Trimethoprim-sulfamethoxazole, Oxacillin, and Cefoxitin. However, Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) detection was 43.75% in full-term and 75% in preterm placental samples. Moreover, two isolates were positive for both <i>mecA</i> and <i>PVL</i> virulent genes, and the rest were positive only for the <i>mecA</i> gene. Interestingly few isolates lacked both characteristic MRSA genes, <i>mecA</i> and <i>PVL</i>. Notably, resistances were more inclined towards preterm samples for antimicrobial susceptibility and MRSA screening. It may be concluded that there is a significant presence of <i>S. aureus</i> in the placenta of mothers with term and preterm deliveries which might be responsible for preterm deliveries. Therefore, judicious use of antibiotics during pregnancies may help prevent preterm births.