CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
oleh: Dalileh Nabi, Hauke Drechsler, Johannes Pschirer, Franz Korn, Nadine Schuler, Stefan Diez, Rolf Jessberger, Mariola Chacón
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-dependent weakening of the spindle assembly checkpoint.