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Malignant glioma, one of the most lethal malignancies, is the most common primary central nervous system tumor with a dismal prognosis. The major obstacle to cure and recurrence is diffuse invasion, which enables glioma cells to escape complete surgical resection and radiotherapy and chemotherapy. Combined with findings in our lab and related articles, this review comprehensively elaborates the therapies target to glioma invasion and migration and relevant molecular mechanisms. DOI：10.3969/j.issn.1672⁃6731.2019.11.004